Catechin Protects Against Dyslipidemia and Nephro- Hepatototoxicity Induced in Rats Exposed to Arsenic
نویسندگان
چکیده
Arsenic poisoning is a major environmental event affecting millions worldwide and its treatment with chelating agents has met with limited success. While arsenic toxicity affects multiple systems in the human body, its mode of action has not been fully elucidated. The present study therefore, investigated the possible protective effects of catechin against hepatorenal damage and dyslipidemia induced by arsenic exposure. Rats were exposed to arsenic (100 ppm) through their drinking water and were treated with catechin (40 mg/kg and 80 mg/kg, body weight) for 30 days. Arsenic exposure resulted in liver dysfunction obvious with increased activities of the hepatic enzymes alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST). This was accompanied with significant elevation of kidney function markers urea and creatinine (p < 0.05). Furthermore, arsenic caused the distortion of lipid metabolism resulting in hypercholesterolemia, hypertriglyceridemia and increased plasma phospholipid in the animals. Co-treatment with catechin effectively protected against arsenic-mediated hepatotoxicity, prevented renal damage and restored lipid homeostasis in the rats. The present data indicate the ability of catechin to potentially prevent arsenic-induced nephrohepatotoxicity and dyslipidemia in rats.
منابع مشابه
The hepatoprotective and antioxidant effects of Curcumin and N-acetylcysteine in rats exposed to arsenic
Introduction: Arsenic is a highly toxic element that is widely distributed in environment. Antioxidants depletion and oxidative stress is now considered as one of the possible mechanisms of arsenic-induced toxicity. N-acetylcysteine (NAC) and Curcumin (Cur) are potential antioxidants that can compensate the depletion of antioxidants. This study aimed to compare the hepatoprotective effect of Cu...
متن کاملInhibitory effect of concomitant administration of Zataria multiflora Boiss. against oxidative damage-induced by sub-acute exposure to arsenic in rats
To evaluate the protective effect of Zataria multiflora boiss. (Zm) extract against arsenic-induced oxidative damage in rats. Rats were orally treated with various doses of Zm (200, 400, and 600 mg/kg) and sodium arsenite (5.5 mg/ kg), alone or in combination, once daily for 30 consecutive days. Twenty-four hours after the last dose, rats were euthanized, and biochemical studies were conducted ...
متن کاملPreconditioning by the inhalation of pure oxygen protects rat’s cochlear function against noise-induced hearing loss
Background: Occupational noise-induced hearing loss (ONIHL) is a hearing disorder that affects workers all over the world. Preconditioning with several mild or less potent stressors will effectively prevent the development of noise-induced hearing loss. This study investigated the possible preventive effects of normobaric hyperoxia preconditioning on preventing the noise-induced hearing impairm...
متن کاملEffects of Vitamin C on Paraoxonase1 Arylesterase Activity in Rats Exposed to Arsenic
Background: Arsenic as an environmental toxicant is able to induced oxidative stress. The present study aimed to evaluate of vitamin C supplementation on the paraoxonase1 (PON1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. Methods: The study was conducted in the Faculty of Veterinary Medicine, Tabriz Islamic Azad University, Tabriz, Iran in 2...
متن کاملProtective Effects of Eugenol against Hepatotoxicity Induced by Arsenic Trioxide: An Antileukemic Drug
Background: Arsenic trioxide (As2O3) has shown effectiveness in the treatment of leukemia, but it is also associated with hepatotoxicity. Given antileukemic drug-induced oxidative stress and toxicity, this study focused on the mitigatory role of eugenol, a monoterpene compound from clove oil, in the hepatic tissue of Wistar rats.Methods: Twenty-four male Wistar rats (180–250 g) were randomly di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016